Janet Thornton- evolution of enzyme mechanisms and functional diversity
Grand vision- an arrow showing the pathway for bioinformatics:
Dictionary– the parts (genes,proteins,etc)
Thesaurus– the interactions
Circuit diagram– the biological networks
Atlas– where (and when) it happetns.
We are only at the thesaurus stage
Data doubles every 5 months
Comparing, clustering, evolution of bio chemistry.
Most enzyme evolution (90%) is within the same enzyme class, adopting to either a new substrate or new product.