Rolf Muller (spelling!!) uses bacteria to produce compounds which inhibit/destroy tuburculosis bacteria. But of course resistance develops.
So, an interesting question: The ones producing the compound have resistance, otherwise they would suicide. The resistance which evolves in the target bugs, does it evolve the same mechanism as the producers use?
Is the resistance capacity built in the genome but turned off in the wild type? Or does it develop a ‘new’ capacity?