Dynamic network of disease phenotype– Hidalgo 2009

Another pub from one of the kings of networks.

Has a huge clinical database. Makes a network of most stated diseases in database, where a link indicates that the two diseases occur in the same patient at a higher than chance frequency.

He uses two measures of association which have opposite biases.
Relative Risk (RR)– overestimates relationships involving rare diseases while discounting common ones
Phi-correlation (phi) accurate for diseases with the same frequency, discounts comorbidity between rare and common disease

The network’s predicitive power is on the same order as family studies and/or some genetic studies.

Some discussion on inferring directionality

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Posted on January 5, 2012, in networks and tagged . Bookmark the permalink. Leave a comment.

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